Theme 1 …

… aims to develop novel second generation laboratory-based, resistance guided therapy tests for Neisseria gonorrhoeae and Mycoplasma genitalium. This Theme will also develop processes to help facilitate the development of new resistance guided therapy tests on point-of-care platforms, ultimately enabling near-patient testing and inform antibiotic choices to optimise patient management.

The remit of this Theme is to:

• Identify new biomarkers of antimicrobial resistance through a combination of bacterial culture, genomics, antimicrobial resistance testing, and analysis of treatment outcomes
• Investigate the mechanistic bases of novel antimicrobial resistance
• Develop and optimise next generation diagnostic tests for antimicrobial resistance, including the simultaneous detection of multiple markers.
• Establish pre-clinical studies to accelerate the development of new diagnostic tests.
• Expand strategies to other sexually transmitted infections prone to antimicrobial resistance.