Optimising STI treatments
Prof Jane Hocking
Ms Julie Phillips
… aims to generate new pharmacokinetic tools and data that can help guide antimicrobial treatments for sexually transmitted infections. It will do this by investigating the pharmacokinetics of current and new antimicrobials. It will use existing pharmacokinetic methods and will also develop innovative new methodologies to measure the pharmacokinetics at different sites of infection. STI treatment efficacy can vary by site of infection, with efficacy often lower for oropharyngeal infections. Lack of pharmacokinetic data for oropharyngeal infections makes treatment optimisation difficult. This Theme will develop protocols for these new methodologies which will enable faster and more comprehensive assessments of compound suitability.
The remit of this Theme is to:
- Investigate the pharmacokinetics/pharmacodynamics of antimicrobial treatments at different anatomical locations with a primary focus on oro-pharyngeal tissues.
- Provide ongoing technical advice and support analysis of new compounds including compound optimisation and new formulations.
- Develop and optimise protocols including alternative sample collection methods to enable pharmacokinetic studies, e.g., VAMS – Volumetric Micro sampling to minimise invasive procedures including cannulation.