… aims to generate new pharmacokinetic tools and data that can help guide antimicrobial treatments for sexually transmitted infections. It will do this by investigating the pharmacokinetics of current and new antimicrobials. It will use existing pharmacokinetic methods and will also develop innovative new methodologies to measure the pharmacokinetics at different sites of infection. STI treatment efficacy can vary by site of infection, with efficacy often lower for oropharyngeal infections. Lack of pharmacokinetic data for oropharyngeal infections makes treatment optimisation difficult. This Theme will develop protocols for these new methodologies which will enable faster and more comprehensive assessments of compound suitability.